Reaching and stepping respond differently to medication and cueing in Parkinson’s disease
Allen Hill 
Hiram Cantú
Julie N. Côté
Julie Nantel
Abstract
The basal ganglia contribute to internal timekeeping, and dopaminergic medication has been observed to moderate timing deficits associated with Parkinson’s Disease (PD) during single joint movements. However, it is unclear whether similar effects can be observed in multi-joint movements. Twenty-five people with PD and twelve healthy peers performed repetitive reaching and stepping-in-place tasks with and without auditory cues at their self-selected maximal cadence. The PD group was measured ON and OFF medication. Reduced cadence error was found for both groups and tasks when cued, and ON PD exhibited decreased cadence compared to OFF PD. Overall timing variability was no different from controls, but differences were found in estimates of clock and motor variance using the Wing-Kristofferson model of interval timing. A medication and cueing interaction during the reaching task produced increased clock variance in uncued, ON PD. During the stepping task, clock and motor variance of the PD group were unaffected by cues, in contrast to the control group. Serial lag-one correlation was reduced in both groups for cued reaching, but was unaffected by cueing or medication in the PD group when stepping-in-place. These findings suggest that overall timing variability may not capture timing deficits in PD.
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Citation
BibTeX citation:
@article{hill2024,
author = {Hill, Allen and Cantú, Hiram and Côté, Julie N. and Nantel,
Julie},
publisher = {Nature Publishing Group},
title = {Reaching and Stepping Respond Differently to Medication and
Cueing in {Parkinson’s} Disease},
journal = {Scientific Reports},
volume = {14},
number = {1},
pages = {24461},
date = {2024-10-18},
url = {https://www.nature.com/articles/s41598-024-72751-y},
doi = {10.1038/s41598-024-72751-y},
langid = {en},
abstract = {The basal ganglia contribute to internal timekeeping, and
dopaminergic medication has been observed to moderate timing
deficits associated with Parkinson’s Disease (PD) during single
joint movements. However, it is unclear whether similar effects can
be observed in multi-joint movements. Twenty-five people with PD and
twelve healthy peers performed repetitive reaching and
stepping-in-place tasks with and without auditory cues at their
self-selected maximal cadence. The PD group was measured ON and OFF
medication. Reduced cadence error was found for both groups and
tasks when cued, and ON PD exhibited decreased cadence compared to
OFF PD. Overall timing variability was no different from controls,
but differences were found in estimates of clock and motor variance
using the Wing-Kristofferson model of interval timing. A medication
and cueing interaction during the reaching task produced increased
clock variance in uncued, ON PD. During the stepping task, clock and
motor variance of the PD group were unaffected by cues, in contrast
to the control group. Serial lag-one correlation was reduced in both
groups for cued reaching, but was unaffected by cueing or medication
in the PD group when stepping-in-place. These findings suggest that
overall timing variability may not capture timing deficits in PD.}
}
For attribution, please cite this work as:
Hill, Allen, Hiram Cantú, Julie N. Côté, and Julie Nantel. 2024.
“Reaching and Stepping Respond Differently to Medication and
Cueing in Parkinson’s Disease.” Scientific Reports 14
(1): 24461. https://doi.org/10.1038/s41598-024-72751-y.